An acute intermittent porphyria (AIP) attack requires immediate attention. This guide provides quick access to information needed to treat an AIP patient during an acute attack.
View Quick Reference GuidePanhematin when reconstituted as directed with sterile water for injection, each 48mL contains the equivalent of approximately 336 mg hematin at a concentration of 7mg/ml1
mL to infuse =
Prescribed Dosage (mg/kg) x Patient Weight (kg)
7 mg/mL Concentration of Reconstituted PANHEMATIN
Monday-Thursday 6:30 PM CT
Friday 6:00 PM CT
Saturday Delivery
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Include any specific delivery instructions when ordering. New to ordering PANHEMATIN? Ask for expedited account setup.
PANHEMATIN is supplied as a sterile, lyophilized black powder in single dose dispensing vials (NDC 55292-702-54) in a carton (NDC 55292-702-55). The vial stopper contains natural rubber latex. Store lyophilized powder at 20-25°C (68-77°F).1
INDICATIONS AND USAGE
PANHEMATIN is a hemin for injection indicated for the amelioration of recurrent attacks of acute intermittent porphyria temporally related to the menstrual cycle in susceptible women, after initial carbohydrate therapy is known or suspected to be inadequate.
Limitations of Use
PANHEMATIN is contraindicated in patients with known hypersensitivity to this drug.
Risk of Phlebitis: Phlebitis is possible. Utilize a large arm vein or a central venous catheter for administration to minimize the risk of phlebitis.
Iron and Serum Ferritin: Elevated iron and serum ferritin may occur. Monitor iron and serum ferritin in patients receiving multiple administrations of PANHEMATIN.
Anticoagulant Effects: PANHEMATIN has transient and mild anticoagulant effect. Avoid concurrent anticoagulant therapy.
Renal Effects: Reversible renal shutdown has been observed with an excessive hematin dose (12.2 mg/kg in a single infusion). Strictly follow recommended dosage guidelines.
Transmissible Infectious Agents: PANHEMATIN may carry a risk of transmitting infectious agents, e.g., viruses, and theoretically, the Creutzfeldt-Jakob disease (CJD) agent. There is also the possibility that unknown infectious agents may be present in the product.
The most common adverse reactions (>1% of patients) are headache, pyrexia, infusion site reactions, and phlebitis.
To report SUSPECTED ADVERSE REACTIONS, contact Recordati Rare Diseases Inc. at 1-888-575-8344, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Drug Interactions: Avoid CYP inducing drugs such as estrogens, barbituric acid derivatives and steroid metabolites which induce δ-aminolevulinic acid synthetase 1 (ALAS1) through a feedback mechanism.
PANHEMATIN® (hemin for injection), for intravenous infusion only, is available as powder for reconstitution in 350 mg vials.
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